The amount of Propofol required for induction of anesthesia when it is given at 1min /3min /5min after injection of fentanyl.

A DOUBLE BLIND RANDOMIZED STUDY TO EVALUATE IF INCREASING THE TIME INTERVAL BETWEEN ADMINISTRATION OF FENTANYL AND PROPOFOL REDUCE THE INDUCTION DOSE OF PROPOFOL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036612

Enrollment

Registered

2021-09-17

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K20-K31- Diseases of esophagus, stomach and duodenum Health Condition 2: H65-H75- Diseases of middle ear and mastoid

Interventions

Intervention1: Propofol after 3 min of fentanyl: Here patients will receive induction dose of propofol after 3min of fentanyl administration Intervention2: Propofol after 5min of fentanyl: Here patien

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status I and II 2. Patients undergoing any elective surgeries under General Anesthesia 3. Patients giving informed valid written consent

Exclusion criteria

Exclusion criteria: 1. Patients refusing to give consent 2. Patients posted for emergency surgeries 3. Patients with anticipated or actual difficult airway 4. Patients with cardiac, renal, hepatic, cerebral diseases 5. Patients allergic to Propofol and / or fentanyl 6. Patients with BMI 30kg/m2 7. Patients with alcohol intake and drug (enzyme inducer) use

Design outcomes

Primary

Measure	Time frame
To measure the total dose of Propofol required for induction of anesthesia following administration of Fentanyl at varying time intervals.Timepoint: Dose of Propofol required will be measured at the end of 1min, 3min and 5min.	—

Secondary

Measure	Time frame
To evaluate the effect of varying time intervals between administration of Fentanyl and Propofol on hemodynamic variables such as hear rate, Systolic BP, Diastolic BP and Mean Arterial Pressure.Timepoint: HR, SBP, DBP, MAP, spo2 measured every minute upto 10 minutes.	—

Countries

India

Contacts

Public ContactDr Basavaraj Kallapur

Karnataka Institute of Medical Sciences

doc_basu@yahoo.co.in8660486142

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026