Study of types of venous Outflow reconstruction in right lobe living donor Liver Transplantation

Multicenter randomized controlled trial of single outflow versus dual outflow for right lobe graft needing anterior sector reconstruction during adult living donor liver transplantation - VOLT

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036589

Enrollment

220

Registered

2021-09-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: K74- Fibrosis and cirrhosis of liver

Interventions

Intervention1: Single hepatic venous Outflow reconstruction of graft: Here the right hepatic vein and the reconstructed anterior sector venous drainage will be joined together on the back-table before

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients undergoing their first liver transplantation for chronic liver disease and receiving a right lobe living donor liver graft

Exclusion criteria

Exclusion criteria: Patients who cannot consent for the study Patients allergic to CT contrast Patients undergoing auxiliary transplantation, retransplantation Patients receiving grafts with no anterior sector outflow reconstruction Patients receiving grafts recovered with total/sub-total MHV Patients in whom deceased donor/autologous vein graft for anterior sector outflow reconstruction

Design outcomes

Primary

Measure	Time frame
Patency of reconstructed anterior sector veinsTimepoint: 6 weeks after liver transplant	—

Secondary

Measure	Time frame
Cold ischemia time Warm ischemia time Intra-operative doppler ultrasound flow pattern of right hepatic vein and anterior sector vein Final portal pressure Timepoint: During liver transplantation surgery;Patency and phasicity of flow in right hepatic vein and anterior sector veinsTimepoint: Post-operative days 1,2,3,5,7,14,30,60,180,365;Post-operative allograft function Drain output Need for intervention for graft venous outflow or for small for size syndromeTimepoint: Immediate post-operative period	—

Measure

Time frame

Cold ischemia time Warm ischemia time Intra-operative doppler ultrasound flow pattern of right hepatic vein and anterior sector vein Final portal pressure Timepoint: During liver transplantation surgery;Patency and phasicity of flow in right hepatic vein and anterior sector veinsTimepoint: Post-operative days 1,2,3,5,7,14,30,60,180,365;Post-operative allograft function Drain output Need for intervention for graft venous outflow or for small for size syndromeTimepoint: Immediate post-operative period

—

Countries

India

Contacts

Public ContactMettu Srinivas Reddy

Institute of Liver Disease and Transplantation

smettu.reddy@gmail.com9840054648

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026