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To find out the efficacy and safety of topical fluorouracil (1%) cream in comparison to clobetasol propionate cream (0.05%) for the treatment of palmoplantar psoriasis

TO STUDY THE COMPARISON OF TOPICAL FLUOROURACIL CREAM (1%) VS CLOBETASOL PROPIONATE CREAM (0.05%) IN PALMOPLANTAR PSORIASIS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036545
Enrollment
100
Registered
2021-09-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L408- Other psoriasis

Interventions

Intervention1: Topical 5-fluorouracil (1%): 5-flourouracil is a cytostatic and immunomodulatory compound. Topical application of 5- Flourouracil (1%) over psoriatic lesions for overnight application (

Sponsors

Dr Prateek Chauhan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria Patients with Lesions covering more than 30% of palms/soles (palmoplantar psoriasis). Patients age >18 years. Patients who give their consent for the study.

Exclusion criteria

Exclusion criteria: Exclusion criteria Patients of age Patients with psoriatic lesions where systemic therapy is needed. Pregnant and Breast feeding females. Patients who had taken topical anti-psoriatic medication in 2 weeks or more before enrollment. Patients who had taken systemic anti-psoriatic medication in 1 month or more before enrollment. Patients who didnâ??t give their consent for the study or have not shown willingness for follow up. Patients on oral steroids or immunosuppressing agents.

Design outcomes

Primary

MeasureTime frame
Morphology of lesions Duration of disease Size of lesion Infiltration Erythema Desquamation PASI score Timepoint: O weeks 2 weeks 4 weeks 6 weeks 8 weeks

Secondary

MeasureTime frame
PASI SCORETimepoint: 0 weeks 2 weeks 4 weeks 6 weeks 8 weeks

Countries

India

Contacts

Public ContactDr Prateek Chauhan

Peoples college of medical science and research centre

animesh7891@gmail.com6262603128

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026