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Effect of anesthesia technique on anti-tumor immunity

Effect of anesthetic technique on anti-tumor immunity in patients undergoing surgery for Gall Bladder Cancer: A prospective randomized comparative study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036528
Enrollment
60
Registered
2021-09-15
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Total Intravenous Anesthesia using Propofol: After adequate preoxygenation, anesthesia will be induced with i.v propofol with a target control infusion pump using Schneider model target

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing surgery for Carcinoma Gall Bladder belonging to ASA class I,II and III

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Allergy to propofol or any study drugs 3. Chronic kidney or liver disease

Design outcomes

Primary

MeasureTime frame
To detect the difference in post-operative serum TGF-β levels in patients receiving Propofol-based Total Intravenous Anesthesia versus inhalational based anesthesiaTimepoint: Pre-operative and 24 hours after surgery—

Secondary

MeasureTime frame
To compare incidence of post-operative complicationsTimepoint: up to 24 hours after surgery;To detect difference in peri-operative systemic inflammation and anti-tumor immunity: change between pre-operative and post-operative T-helper cell profile, IL-6, NLR, PLR, MLR and modified Glasgow prognostic scoreTimepoint: Pre-operative and 24 hours after surgery—

Countries

India

Contacts

Public ContactAnkit Sharma

Dr BRA IRCH, AIIMS

ankitmamc@gmail.com9910517566

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026