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Understanding the cellular immune responses in Indian tuberculosis and melioidosis patients

Characterising the cellular immunity and metabolic response to Mycobacterium tuberculosis and Burkholderia pseudomallei in Indian patients

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/09/036508
Enrollment
194
Registered
2021-09-14
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B998- Other infectious disease Health Condition 2: A150- Tuberculosis of lung

Interventions

None listed

Sponsors

VALIDATE PumpPriming Grant Medical Research Council MRC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with culture /PCR confirmed melioidosis. Patients diagnosed with tuberculosis confirmed by smear positive and/or Gene Xpert. Age and Gender matched healthy controls with and without diabetes mellitus

Exclusion criteria

Exclusion criteria: Patients below 18 years of age

Design outcomes

Primary

MeasureTime frame
1. To determine the antigen specific cellular response during TB and melioidosis in Indian subjects 2. To determine the differences in the cellular metabolism of TB and melioidosis patients with and without diabetes mellitusTimepoint: 2 years—

Secondary

MeasureTime frame
To know the role of difference in cellular metabolism of diabetes mellitus leading to increased susceptibility to TB and melioidosisTimepoint: 1 year—

Countries

India

Contacts

Public ContactDr Chiranjay Mukhopadhyay

Kasturba Medical College, Manipal Academy of Higher Education

chiranjay.m@manipal.edu9845513057

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026