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TO STUDY THE RELATION OF ALKALINE PHOSPHATASE ENZYME ACTIVITY IN GINGIVAL CREVICULAR FUILD WITH THE RATE OF TOOTH MOVEMENT FASTENED BY PLATELET RICH PLASMA INJECTION

EVALUATION OF RELATION BETWEEN ALKALINE PHOSPHATASE ACTIVITY IN GINGIVAL CREVICULAR FLUID WITH THE RATE OF TOOTH MOVEMENT ACCELERATED BY PLATELET RICH PLASMA INJECTION - IN VIVO STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036459
Enrollment
10
Registered
2021-09-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: platelet rich plasma: collection of gingival crevicular fluid following platelet rich plasma administration as an adjuvant on the experimental side during retraction phase with the conv

Sponsors

DR BHARAT KRISHNAN C K
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: class I bimaxillary malocclusion needing all first premolar extractions

Exclusion criteria

Exclusion criteria: Patients under any other medication which affects tooth movement Patients with craniofacial anomalies Patients with periodontal disease Patients with any kind of systemic disease that affects tooth movement

Design outcomes

Primary

MeasureTime frame
The level of ALP in the GCF of experimental side canine and molar and control side canine is evaluated.Timepoint: The GCF samples from the experimental canine and molar and control canine will be evaluated for the ALP levels using Human ALP ELISA test kit at T0(baseline), T1(21st day), T2(3rd month).

Secondary

MeasureTime frame
1.The rate and amount of tooth movement in Platelet rich plasma administered side and non administered side 2.The anchorage loss on the experiment and non experiment side.Timepoint: 1.The amount and rate of tooth movement will be measured from the distal surface of canine and mesial surface of the second premolar at T0(before start of retraction), T1(1st month),T2(2nd month),T3(3rd month) and T4(4th month) 2.The lateral cephalogram will be taken at T0(baseline) and T1(3rd month)to assess the position of molar with respect to any stable landmark

Countries

India

Contacts

Public ContactDR BHARAT KRISHNAN C K

FACULTY OF DENTAL SCIENCES, MS RAMAIAH UNIVERSITY OF APPLIED SCIENCES

pacchi77@yahoo.com9886242624

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026