Volume of 0.5% ropivacaine needed to produce anaesthesia of upper limb in 50% of patients using ultrasound guided multiple injection lateral sagittal infraclavicular plexsus block

Median effective volume of 0.5% ropivacaine for ultrasound guided multiple injection lateral sagittal infraclavicular plexus block: a dose finding study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036445

Enrollment

Registered

2021-09-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: M968- Other intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified

Interventions

Intervention1: Ultrasound-guided Infraclavicular block: The patients will be placed supine with the arm to be blocked abducted. We will use a high-frequency (5â??12 MHz) ultrasound probe (Sonosite, In

however, if a cord could not be imaged, local anaesthetic placement will be done on an arbitrary basis according to an imaginary clock face in the following sequential order: posterior cord at 6 oâ??c

Eligibility

Inclusion criteria

Inclusion criteria: Patients with American Society of Anesthesiologists (ASA) physical status I-II patients, in the age group of 18-60 years, with a body mass index (BMI) between 18 and 30 kg.m-2, scheduled to undergo forearm and hand surgeries will be assessed for eligibility

Exclusion criteria

Exclusion criteria: Patients with local infection at the block site, coagulopathy, sepsis, BMI >30, allergy to local anesthetics, uncontrolled hypertension or ischemic heart disease, renal or hepatic dysfunction, pre-existing neurological deficits, prior surgery in the infraclavicular fossa, psychiatric illness, patients who failed to understand the scoring systems used in the study and patients who refused to give consent for the study will be excluded.

Design outcomes

Primary

Measure	Time frame
The primary objective will be to estimate MEV90 for multiple-injection US-guided ICB. Volume assignment will be carried out using a biased coin design (BCD) up-and-down sequential method (UDM), where the volume administered to each patient will depend upon the response of previous patient. First subject will receive 21 ml based upon a previous study MEV50 of 19 ml in patients receiving ultrasound-guided LSIB with ropivacaine 7.5 mg/ml. based on the response of the previous patient. In case of failure, the next subject will receive a higher volume (0.5ml/ cord). If the previous patient had a successful block, the next subject will be randomized to a lower volumeTimepoint: 30 minutes after performance of block	—

Measure

Time frame

The primary objective will be to estimate MEV90 for multiple-injection US-guided ICB. Volume assignment will be carried out using a biased coin design (BCD) up-and-down sequential method (UDM), where the volume administered to each patient will depend upon the response of previous patient. First subject will receive 21 ml based upon a previous study MEV50 of 19 ml in patients receiving ultrasound-guided LSIB with ropivacaine 7.5 mg/ml. based on the response of the previous patient. In case of failure, the next subject will receive a higher volume (0.5ml/ cord). If the previous patient had a successful block, the next subject will be randomized to a lower volumeTimepoint: 30 minutes after performance of block

—

Secondary

Measure	Time frame
Time to requirement of first bolus, mean pain scores at various time intervalsTimepoint: Baseline ie on shifting to PACU, 2hrs, 4hrs , 8hrs, 12hrs, 24hrs	—

Countries

India

Contacts

Public ContactJeetinder Kaur Makkar

Post Graduate Institute of Medical Education and Research

jeet1516@gmail.com7087009510

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026