Health Condition 1: N89- Other noninflammatory disorders ofvagina Health Condition 2: N898- Other specified noninflammatory disorders of vagina Health Condition 3: N898- Other specified noninflammatory disorders of vagina
Conditions
Interventions
Control Intervention1: Metagenomic Sequencing: Metagenomic sequencing is a molecular tool used to analyze DNA in order to study the community of microflora present without the need of isolating pure c
Sponsors
Dr Baljinder Kaur
Self funded
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy subjects - Women visiting the Gynecology OPD for regular health checkup or seeking contraception. 2. Bacterial Vaginosis - Women visiting the Gynecology OPD having discharge, abdominal pain,and infertility.
Exclusion criteria
Exclusion criteria: Healthy Subjects - Women who are pregnant, menstruating, handicapped or on any other medication for any other illness. Bacterial Vaginosis - Women who are pregnant, menstruating, handicapped or on any other medication for any other illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Metagenomics will reveal identity of pathogens associated with Baterial Vaginosis. Biological diversities (alpha and beta diversities)of Bacterial Vaginosis infected human vaginal ecosystem w.r.t. healthy vagina will be revealed to predict actual pathophysiology of Bacterial Vaginosis. 2. Comparative assessment of efficacy of antibiotics vs. probiotics to control Bacterial Vaginosis in humans.Timepoint: year1-comparitive metagenomic profiling of the healthy human and Bacterial Vaginosis infected vaginal microflora; Year2-Selection of best antibiotc and probiotic formulations for proposing best anti bacterial vaginosis therapy;year3-Comparitive vaginal metagenomic profiling of antibiotic treated and probiotic treated bacterial vaginosis patients for investigating treatment efficiencies. | — |
Secondary
| Measure | Time frame |
|---|---|
| Proposing probiotic solutions for drug resistant Bacterial Vaginosis pathogens.Timepoint: Metagenomic profiling of healthy humans-1-6months; metagenomic profiling of Bacterial Vaginosis patients -7-12months; selection of best antibiotic and probiotic formulation -13-24months; metagenomic profiling of antibiotic and probiotic treated Bacterial vaginosis patient-24-36months | — |
Countries
India
Contacts
Public ContactPriya Daroch
Punjabi University, Patiala
Outcome results
None listed