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STUDY OF VARIATION IN OPRM1 Al18G AND ITS CORRELATION WITH DIFFERENCE IN THE INCIDENCE of NAUSEA VOMITING AFTER FEMUR FRACTURE SURGERY IN PATIENTS RECEIVING TRAMADOL FOR PAIN RELIEF

OPRM 1 Al18G GENE POLYMORPHISM AND INTERINDIVIDUAL DIFFERENCE IN POSTOPERATIVE NAUSEA VOMITING INDUCED BY POSTOPERATIVE TRAMADOL IN PATIENTS UNDERGOING FEMUR FRACTURE SURGERY -A PROSPECTIVE OBSERVATIONAL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/09/036433
Enrollment
50
Registered
2021-09-13
Start date
Unknown
Completion date
Unknown
Last updated
2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M959- Acquired deformity of musculoskeletal system, unspecified

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

University College of Medical Sciences and GTB Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I or II undergoing isolated femur fracture surgeries under spinal anaesthesia

Exclusion criteria

Exclusion criteria: history of significant cardiac, hepatic or renal disease; Patients having nausea or vomiting 24 hours before surgery and/or those receiving any other antiemetics within last 24 hour and a known hypersensitivity to 5HT3 agents

Design outcomes

Primary

MeasureTime frame
To correlate PONV score amongst different specific OPRM1 A118G allele groupsTimepoint: Baseline venous blood sample for gene polymorphism study before the surgery—

Secondary

MeasureTime frame
To assess the incidence of nausea and vomiting amongst different specific OPRM1 A118G allele groupsTimepoint: Baseline venous sample for gene polymorphism study before the surgery—

Countries

India

Contacts

Public ContactDr Pankaj Dixit

University College of Medical Sciences and GTB Hospital,

donottry11@gmail.com9911454821

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026