Depth of Anaesthesia monitoring- Isoflurane vs Sevoflurane

Comparison of effect of different MAC values on Bispectral index for Isoflurane vs Sevoflurane Anaesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036403

Enrollment

Registered

2021-09-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N202- Calculus of kidney with calculus of ureter Health Condition 2: N22- Calculus of urinary tract in diseases classified elsewhere Health Condition 3: N186- End stage renal disease Health Condition 4: O- Medical and Surgical

Interventions

Intervention1: Isoflurane group: Measurement of Bispectral index at different MAC values of isoflurane Control Intervention1: Sevoflurane Group: Measurement of Bispectral index at different MAC values

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II

Exclusion criteria

Exclusion criteria: Patients on sedatives and hypnotics preoperatively Hemodynamically unstable patients Patients with altered sensorium Patients with psychiatric illness and alcohol/substance abuse

Design outcomes

Primary

Measure	Time frame
BIS measurement at different MAC values(0.5,0.7,1,1.2,1.5) of Isoflurane BIS measurement at different MAC values (0.5,0.7,1,1.2,1.5) Hemodynamic monitoring at different MAC values of Isoflurane and Sevoflurane( Heart rate , Blood pressure and Mean arterial pressure)Timepoint: BIS measurement at different MAC values(0.5,0.7,1,1.2,1.5) of Isoflurane - BIS measurement at different MAC values (0.5,0.7,1,1.2,1.5) Hemodynamic monitoring at different MAC values of Isoflurane and Sevoflurane( Heart rate , Blood pressure and Mean arterial pressure) after 10 mins after each MAC value is achieved.Duration- 2 minutes prior to intubation till 5 minutes prior to extubation	—

Measure

Time frame

BIS measurement at different MAC values(0.5,0.7,1,1.2,1.5) of Isoflurane BIS measurement at different MAC values (0.5,0.7,1,1.2,1.5) Hemodynamic monitoring at different MAC values of Isoflurane and Sevoflurane( Heart rate , Blood pressure and Mean arterial pressure)Timepoint: BIS measurement at different MAC values(0.5,0.7,1,1.2,1.5) of Isoflurane - BIS measurement at different MAC values (0.5,0.7,1,1.2,1.5) Hemodynamic monitoring at different MAC values of Isoflurane and Sevoflurane( Heart rate , Blood pressure and Mean arterial pressure) after 10 mins after each MAC value is achieved.Duration- 2 minutes prior to intubation till 5 minutes prior to extubation

—

Secondary

Measure	Time frame
To figure out inhalation agent Sevoflurane vs Isoflurane with better hemodynamic stabilityTimepoint: BIS measurement and hemodynamic parameters (SBP,DBP,PR,MAP) 10 mins after each MAC is achieved ie( 0.5,0.7,1,1.2,1.5). Duration -10 minutes prior to the start of surgery till 24 hours post surgery to monitor any intraoperative awareness during Anesthesia	—

Countries

India

Contacts

Public ContactSurya Teja J

Dy Patil Medical College and hospital,Pimpri

draparnabagle@gmail.com9422710943

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026