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To compare the effectiveness of propofol vs Esmolol on blunting the hemodynamic response to extubation in abdominal surgeries.

To compare the effectiveness of propofol vs esmolol on attenuation of hemodynamic response to extubation in abdominal surgeries: A comparative randomised double blind interventional study at SMS Hospital jaipur.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036373
Enrollment
72
Registered
2021-09-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K928- Other specified diseases of the digestive system

Interventions

Intervention1: Esmolol 1.5mg/kg i.v.: Esmolol 1.5mg/kg i.v. is given 2 minutes before extubation and hemodynamic response is noted over 10 minutes. Control Intervention1: Propofol 0.5mg/kg i.v.: Propo

Sponsors

SMS Medical College jaipur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II Age group 20-40yrs Weight between 40 and 80 kg Elective abdominal surgeries.

Exclusion criteria

Exclusion criteria: Patients not willing to participate in the study. Patient allergic to the study drug. Patients undergoing laproscopic surgery. Patients with difficult airway.

Design outcomes

Primary

MeasureTime frame
To determine the difference in post extubation SBP, DBP, MAP and Heart Rate from baseline to extubation in both study. groups (esmolol vs propofol). Timepoint: To compare the above mentioned parameters at: 1. After giving reversal 2. Before extubation 3. 1, 3 , 5 and 10 minutes post extubation—

Secondary

MeasureTime frame
1.)Difference in mean sedation score at extubation in both study group. 2.)To determine the difference in proportion of cases experiencing side effects in both groups if any. Timepoint: To asses the above mentioned parameters at: 1. After giving reversal 2. Before extubation 3. 1, 3 , 5 and 10 minutes post extubation—

Countries

India

Contacts

Public ContactDr Deepti Shah

RUHS

fareedahmed10@gmail.com9414787759

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026