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Comparing effect of drug Melatonin in reducing stress response to anesthesia interventions during bypass heart surgery in smokers and non smokers

Effect of MELATONIN premedication on hemodynamic changes during tracheal intubation in cigarette smokers compared with non-smokers in patients undergoing elective off-pump CABG surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036367
Enrollment
38
Registered
2021-09-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I259- Chronic ischemic heart disease, unspecified

Interventions

Intervention1: TABLET MELATONIN: Effect of MELATONIN premedication on hemodynamic changes during tracheal intubation in cigarette smokers compared with non-smokers in patients undergoing elective off-

Sponsors

A J INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients scheduled for elective CABG surgery belonging to patientâ??s physical status American Society of Anesthesiologists (ASA) classes 1,2,3&4 with history of cigarette smoking- 10 or more cigarettes per day for more than one year and non-smoker patients.

Exclusion criteria

Exclusion criteria: 1.Patients with history of OSA 2.Patients with hypovolemia 3.Patients with history of bronchial asthma 4.Patients with history of laryngeal or tracheal surgery 5.Patients with persistent pre-induction BP->=160/90 mm of hg 6.Patients with anticipated difficult airway 7.Patients with ASA class 5 or more 8.Duration of Laryngoscopy >1 Minute 9.More than 1 attempt of intubation 10.Laryngoscopic grade >2B

Design outcomes

Primary

MeasureTime frame
Primary outcome- To find out the hypnotic efficacy of oral Melatonin on hemodynamic changes during tracheal intubation in smokers and non-smokers undergoing elective off-pump CABG surgery. Timepoint: Maximum rise of HR and MAP were noted during tracheal intubation. Heart rate, SAP, DAP, and MAP were recorded after stabilization of patient for 3 minutes before induction, during intubation, and at 1,2, 3, 5, and 10 min after intubation.—

Secondary

MeasureTime frame
Secondary outcome- 1.Comparison of hemodynamic changes during tracheal intubation in smokers and non-smokers. 2.Hemodynamic changes during tracheal intubation. 3.Side effects of the drug administered.Timepoint: Maximum rise of HR and MAP were noted during tracheal intubation. Heart rate, SAP, DAP, and MAP were recorded after stabilization of patient for 3 minutes before induction, during intubation, and at 1,2, 3, 5, and 10 min after intubation—

Countries

India

Contacts

Public ContactSUHAS M K

A J INSTITUTE OF MEDICAL SCIENCES

drsmk84@gmail.com9633565911

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026