Health Condition 1: K74- Fibrosis and cirrhosis of liver
Conditions
Interventions
None listed
Sponsors
Dr Rela Institute and Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patient who will undergo living donor liver transplantation â?? both Adult and Paediatric
Exclusion criteria
Exclusion criteria: 1.Patient undergoing deceased donor liver transplantation 2.Follow up 3.Transplant for ALF patient 4.Twin donor-recipient pair
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Estimation of dd-cfDNA in liver transplant recipient and its role in predicting the post-liver transplant course and specifically of ACR episodes 2. Evaluation of course of TTV load dynamics and its association with biopsy proven ACR episodes Timepoint: ddcfDNA estimation Method- ddPCR and qPCR at several time points- 1. On day 1 2. on day3 3. on day7 4. on day 14 5. before biopsy during 1st year TTV detection Method- by PCR at several time points- 1. Before transplant 2. at day3 3. at 3 months, 6 months and 12 months 4. before any liver biopsy during 1st year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Diagnostic and predictive accuracy of these biomarkers 2. Relation of TTV load and post transplant clinical/laboratory parameters 3. Subgroup analysis between rejection and non-rejection group, pediatric and adult population Timepoint: ddcfDNA estimation Method- ddPCR and qPCR at several time points- 1. On day 1 2. on day3 3. on day7 4. on day 14 5. before biopsy during 1st year TTV detection Method- by PCR at several time points- 1. Before transplant 2. at day3 3. at 3 months, 6 months and 12 months 4. before any liver biopsy during 1st year | — |
Countries
India
Contacts
Public ContactAshwin Rammohan
Dr Rela Institute and Medical Centre
Outcome results
None listed