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Comparing and evaluating levels of SIRT-1 levels in normal and periodontitis affected patients

Evaluation and comparison of Sirtuin 1 (SIRT-1) levels in serum of periodontally healthy and diseased subjects and its response to non surgical periodontal treatment : A clinico-biochemical study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036287
Enrollment
50
Registered
2021-09-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Scalig ad root planing, oral hygiene instructionns: All patients with chronic periodontitis will be treated with scaling and root planing in a single sitting followed by oral hygiene in

Sponsors

TPCTs Terna Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Individuals with good general health and age between 18-60 years. 2. Subjects who have not received periodontal therapy, in the previous six months. 3. Subjects who readily give informed consent for the study. 4. Systemically healthy patients .

Exclusion criteria

Exclusion criteria: 1. Consumption of tobacco in any form and alcoholics. 2. Pregnant and lactating females. 3. Subjects who have received anti-inflammatory, antibiotic and steroid drugs in previous three months

Design outcomes

Primary

MeasureTime frame
a) To determine the level of Sirtuin-1 in serum of periodontally healthy patients. b) To determine the level of Sirtuin-1 in serum of chronic periodontitis patients. c) To compare the levels of Sirtuin-1 in serum of periodontally healthy and chronic periodontitis patients. d) To compare the serum levels of Sirtuin-1 before and after scaling and root planing in chronic periodontitis patients.Timepoint: Baseline 4 weeks after scaling and root planing

Secondary

MeasureTime frame
To evaluate improvement in plaque index, gingival index,pocket probing depth and clinical attachment level in patients with chronic periodontitis 4 weeks after scaling and root planing.Timepoint: Plaque index, gingival index, pocket probing depth and clinical attachment level in patients with chronic periodontitis will be taken at baseline and then 4 weeks after scaling and root planing

Countries

India

Contacts

Public ContactRuchi Chandak

Terna Dental College and Hospital

desaiankit_2000@yahoo.com9920789319

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026