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Comparison of two different doses of labetalol for changes in hemodynamics during intubation in abdominal surgeries.

A Comparative study of effectiveness of two different doses of labetalol in attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation in controlled hypertensive patients under general anesthesia in major abdominal surgeries: A Randomised Double Blind Interventional Study at SMS hospital Jaipur during year 2020-2022

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/09/036263
Enrollment
72
Registered
2021-09-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Intervention1: nil: nil Intervention2: 36 patients will receive 0.15mg/kg inj. labetalol I.v: Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure recorded at time of

Sponsors

Department of Anesthesia SMS medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I&II Age rangr 20-60years Weight range 40-80kgs Patient of both sex Elective open abdominal surgery requiring general anesthesia with endotracheal intubation for more than 1 hour

Exclusion criteria

Exclusion criteria: Patients not willing to participate in study Patients with allergic to study drug Patient with laparoscopic surgery Patient with difficult airway Patient with history of bronchospasm, cardiac disorder,severe hepatic or renal disease and diabetes mellitus

Design outcomes

Primary

MeasureTime frame
To determine the difference in variation in heart rate systolic blood pressure diastolic blood pressure, mean arterial pressure from baseline to 1 minute, 3 minute, 5 minute, and 10 minute post intubation in both groups.Timepoint: 4 months

Secondary

MeasureTime frame
To determine the difference when percentage of cases who experienced side effects within 24 hours in both groups.Timepoint: 4months

Countries

India

Contacts

Public ContactRicha nagar

Sawai Man Singh hospital

fareedahmed10@gmail.com9414787759

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026