A ckinical trial to study the effect of the three different low doses of intranasal dexmedetomidine in attenuation of hemodynamic responses to laryngoscopy.

Comparison of the three different low doses of intranasal dexmedetomidine in attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation .

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036222

Enrollment

Registered

2021-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Is to arrive at an optimal dose of intranasal dexmedetomidine by Comparing between three different low doses to attenuate stress response during laryngoscopy and endotracheal intubatio

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA Grade I & II

Exclusion criteria

Exclusion criteria: 1. ASA >II 2. Predicted difficult airway with anticipated difficult intubation 3. Patient with nasal ulcer, polyp, nasal septum deviation 4. Allergy to any of used drugs 5. Patient with cardiac, renal, or hepatic dysfunction 6. Sinus bradycardia and heart block. 7. Patients on Ã?-blocker 8. Patients on calcium channel blocker 9. Pregnant and lactating women 10. Raised ICT(intra cranial tension) 11. Psychiatric patient

Design outcomes

Primary

Measure	Time frame
Is to arrive at an optimal dose of intranasal dexmedetomidine by Comparing between three different low doses to attenuate stress response during laryngoscopy and endotracheal intubation.Timepoint: Comparision of haemodynamic parameter in pre operative and immediate post intubation period (SBP, DBP, MAP, Pulse rate, SpO2) between 3 groups from 40 min before induction at every 10 min interval till induction of anaesthesia, thereafter at 1min,5 min, and 10 min after intubation.	—

Measure

Time frame

Is to arrive at an optimal dose of intranasal dexmedetomidine by Comparing between three different low doses to attenuate stress response during laryngoscopy and endotracheal intubation.Timepoint: Comparision of haemodynamic parameter in pre operative and immediate post intubation period (SBP, DBP, MAP, Pulse rate, SpO2) between 3 groups from 40 min before induction at every 10 min interval till induction of anaesthesia, thereafter at 1min,5 min, and 10 min after intubation.

—

Secondary

Measure	Time frame
To observe any side effects and complications related to drugs and procedure.Timepoint: at baseline	—

Countries

India

Contacts

Public ContactDr Pramila Soni

Sardar patel medical college

drpramila82@gmail.com9468940551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026