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Comparison of effect of intravenous 2 drugs (Magnesium sulphate and Dexmedetomidine) on intra-operative dose requirement of an anaesthetic agent (propofol), changes in vital parameters and recovery from anaesthesia in patients undergoing laparoscopic cholecystectomy

"Comparison of effect of intravenous Magnesium sulphate and dexmedetomidine on intra- operative propofol requirement,haemodynamics and recovery profile in patients undergoing laparoscopic cholecystectomy:A prospective observational study"

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/09/036199
Enrollment
60
Registered
2021-09-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K810- Acute cholecystitis Health Condition 2: K812- Acute cholecystitis with chronic cholecystitis Health Condition 3: K800- Calculus of gallbladder with acutecholecystitis Health Condition 4: K801- Calculus of gallbladder with othercholecystitis Health Condition 5: K802- Calculus of gallbladder without cholecystitis Health Condition 6: K824- Cholesterolosis of gallbladder Health Condition 7: K811- Chronic cholecystitis Health Condition 8: K829- Disease of gallbladder, unspec

Interventions

Intervention1: Nil: Nil Control Intervention1: Intravenous Magnesium sulphate: magnesium sulphate potentiates anaesthetic effect & N methyl D aspartate(NMDA) antagonism and also hypotensive effect of

Sponsors

Government medical College new civil hospital surat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: a)Patients belonging to ASA gradeI,II or III. b)Patients between the age group of 18-60 years of either sex. c)Patients posted for laparoscopic cholecystectomy surgeries under general anaesthesia. d)Patients giving valid informed written consent.

Exclusion criteria

Exclusion criteria: a)Patients with BMI >30kg/m2. b)Patients with major hepatic,renal,cardio-respiratory disorder and neuromuscular disorders c)Patients with pregnancy,epilepsy,postural hypotension. d)Patient who are taking CCBs,B-blockers,opioidsorsedatives. e)Patients having allergy to studydrugs.. f)Known or suspected difficult airway.

Design outcomes

Primary

MeasureTime frame
To compare 1) Intra-operative propofol requirements in mg/kg/hr 2) Recovery Profile 3) Post operative sedation with Ramsay sedation scoreTimepoint: From baseline to 12 hours—

Secondary

MeasureTime frame
To compare 1) Intra-operative haemodynamic changes. 2) Adverse effects if any.Timepoint: Minimum 3 hours—

Countries

India

Contacts

Public ContactDr Ami PravinKumar Patel

Government Medical College Surat Gujarat

bansarikantharia@gmail.com8849008114

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026