Treatment of bed sore with Platelet rich plasma in patients with spinal cord injury

Effectiveness of autologous platelet rich plasma for the treatment of pressure ulcers in people with spinal cord injury: a randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036188

Enrollment

Registered

2021-09-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Spinal cord injured

Interventions

Intervention1: Platelet Rich Plasma (PRP): PRP gel will be applied locally in the form of dressing on the included PU. participants will receive platelet rich plasma application. In addition they will

Eligibility

Inclusion criteria

Inclusion criteria: 1. Participants with age more than 18 and less than 65 years. 2. Participants or close relative must be able to give voluntary written consent. 3. Participants with sacral PU with 4. Pressure ulcer of grade III & IV will be included in the study. 5. Participant who hospitalized for rehabilitation at ISIC will be included in the study.

Exclusion criteria

Exclusion criteria: 1. Mental, psychiatric or cognitive disorder and /or pre-existing medical condition that might interfere with the outcomes. 2. Pressure sores associated with osteomyelitis, malignancy, leprosy and HIV (+ve) 3. Platelet dysfunction 4. Arterial origin of the cutaneous ulcers. 5. Active vasculitis, 6. Systemic lupus erythematosus, cryoglobulinemia, 7. Hematological abnormality or any coagulation abnormalities. 8. Current use of anticoagulants and/or treatment with immunosuppressant drugs; 9. Serum hemoglobin concentration 10. Participant taking drug which might interfere with the study intervention like Anti- neoplastic drugs, steroids, antibiotics etc. 11. Drug or alcohol abuse.. 12. Patient who smokes will be excluded from the study. 13. Diabetes (controlled/ Uncontrolled), uncontrolled hypertension, autoimmune disease, renal failure.

Design outcomes

Primary

Measure	Time frame
Size of pressure ulcer (percentage of surface area healed).Timepoint: 5 week and 3 month	—

Secondary

Measure	Time frame
Pressure Ulcers Scale for Healing (PUSH) Depth of pressure ulcers Quality of Life using SF 36 4. Participant impression of change using visual analogue scale (VAS) 5. Clinician impression of change using VAS 6. Participantsâ?? satisfaction using VAS 7. Histo-pathological resultsTimepoint: 3 month from the day of randomization	—

Countries

India

Contacts

Public ContactDr Puja S Nagpal

Indian spinal injuries center new Delhi

drhschhabra@isiconline.org

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026