DOSIMETRIC BENEFIT OF DEEP INSPIRATION BREATH-HOLD TECHNIQUE FOR PATIENTS WITH LEFT BREAST CANCER RECEIVING RADIATION POST MASTECTOMY

Dosimetric comparison of free breathing versus deep inspiration breath-hold technique while radiating patients with left sided breast cancer post mastectomy.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036178

Enrollment

Registered

2021-09-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C509- Malignant neoplasm of breast of unspecified site

Interventions

Intervention1: DEEP INSPIRATION BREATH HOLD TECHNIQUE: All the patients will be treated on Image Guided Radiotherapy (IGRT) machine. Firstly, all the patients will undergo two sets of CT scans in supi

Eligibility

Inclusion criteria

Inclusion criteria: 1. Histologically proven cases of left sided breast carcinoma after mastectomy with or without lymph node positivity planned for DIBH-RT. 2. Karnofskyâ??s performance scale score (KPS) greater than or equal to 70

Exclusion criteria

Exclusion criteria: 1. Patients with BCS 2. Right sided breast carcinoma 3. Metastatic disease 4. KPS score 5. Patients with medical history of active cardiac diseases like arrhythmias, myocardial infarction, and congestive heart failure. 6. Inability to establish a reproducible breathing pattern. 7. Inability to maintain breath holding for 20secs at least due to compromised lung function. 8. Need for sedation. 9. Patients with flap reconstruction. 10. Patient refusal.

Design outcomes

Primary

Measure	Time frame
To compare the following parameters in patients undergoing radiation therapy by DIBH with FB technique. 1. Mean heart dose 2. Maximum heart dose 3. Mean LAD dose 4. Maximum LAD dose 5. Mean ipsilateral lung dose 6. Heart-chest wall separation 7. V5 heart 8. V25 heart 9. V5 ipsilateral lung 10. V20 ipsilateral lung 11. Mean contralateral breast dose 12. Mean contralateral lung dose 13. V2 contralateral lung 14. V5 contralateral lung Timepoint: After treatment planning.	—

Measure

Time frame

To compare the following parameters in patients undergoing radiation therapy by DIBH with FB technique. 1. Mean heart dose 2. Maximum heart dose 3. Mean LAD dose 4. Maximum LAD dose 5. Mean ipsilateral lung dose 6. Heart-chest wall separation 7. V5 heart 8. V25 heart 9. V5 ipsilateral lung 10. V20 ipsilateral lung 11. Mean contralateral breast dose 12. Mean contralateral lung dose 13. V2 contralateral lung 14. V5 contralateral lung Timepoint: After treatment planning.

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Secondary

Measure	Time frame
nilTimepoint: nil	—

Countries

India

Contacts

Public ContactDrVigneshwaran

POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH

drbudhi@gmail.com9815981176

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026