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Role of NGAL in Acute Kidney injury with Liver cirrhosis

Clinical profile and outcome of acute kidney injury in chronic liver disease: Role of novel biomarker NGAL in differential diagnosis of acute kidney injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/09/036171
Enrollment
188
Registered
2021-09-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K746- Other and unspecified cirrhosis ofliver

Interventions

None listed

Sponsors

Kasturba Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Clinically diagnosed with cirrhosis of the liver with AKI as per ICA criteria

Exclusion criteria

Exclusion criteria: Kidney or liver transplant Chronic hemodialysis before admission or receiving nephrotoxic medications. Chronic kidney disease Renal insufficiency or urinary obstruction Hepatocellular carcinoma or any other advanced malignancy UTI (Urinary tract infection) (Positive urine culture or urine WBC > 10 per high power field) Septic shock Lack of informed consent

Design outcomes

Primary

MeasureTime frame
To study the clinical profile, risk factors for AKI in Liver cirrhosis patients. To study the impact of type and severity of AKI on mortality and hospital stayTimepoint: 2 years

Secondary

MeasureTime frame
To determine the ability of uNGAL to differentiate different types of AKI. To determine the optimal cut-off value of uNGAL in different types of AKI using ROC curve analysis. To see the correlation of Urine NGAL with severity of AKI in Cirrhosis of liver To study the association of urine NGAL level with 90-day mortality in Cirrhosis of liver.Timepoint: 2 years

Countries

India

Contacts

Public ContactDr Shiran Shetty

Kasturba Medical College

shiran.shetty@manipal.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026