Importance of Madua (Eleusine Coracana) rice starch in Tablet formulation

GASTROINTESTINAL RETENTION TIME BY X-RAY IMAGING OF SOLID DOSAGE FORM CONTAINING EXTRACTED MANDUA STARCH AS DRUG CARRIER - CDDS

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/09/036142

Enrollment

Registered

2021-09-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Placebo tablet containing alkali extracted mandua starch (800mg): Tablets will made by alkali-treated Mandua starch and treated starch by phosphorylation, acetylation and epichlorohydri

Eligibility

Inclusion criteria

Inclusion criteria: The patient has no history of disease for which he/She is taking medicine presently.

Exclusion criteria

Exclusion criteria: Patients having hypertension due to other secondary diseases- Renal disease Due to other drugs Endocrinal diseases Coarctation of aorta Neurogenic causes Coeliac or Colonic disease Any other serious medical & surgically ill patients. Patients having the complication of hypertension

Design outcomes

Primary

Measure	Time frame
To know the region of the Gastrointestinal tract at which the tablet disintegrates completely and whether the tablet reaches in the intact form up to the colon part of the gastrointestinal tract. Effectiveness of Madua containing tablet for targeted drug delivery to the colon site for the treatment of disease of the colonic region.Timepoint: Assessment-The assessment will be done at an interval of 2, 4, 8 and 24 hr after oral administration of the tablet.	—

Measure

Time frame

To know the region of the Gastrointestinal tract at which the tablet disintegrates completely and whether the tablet reaches in the intact form up to the colon part of the gastrointestinal tract. Effectiveness of Madua containing tablet for targeted drug delivery to the colon site for the treatment of disease of the colonic region.Timepoint: Assessment-The assessment will be done at an interval of 2, 4, 8 and 24 hr after oral administration of the tablet.

—

Secondary

Measure	Time frame
Tablet is effective for selective drug delivery fro colon specific drugsTimepoint: 2nd day	—

Countries

India

Contacts

Public ContactDr Vipin kumar

Department of Kaya Chikitsa Uttarakhand Ayurved University, Rishikul Campus, Haridwar

dr.opsingh63@gmail.com9411503035

Outcome results