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A RANDOMISED COMPARITIVE STUDY BETWEEN DEXMEDETOMEDINE AND CLONIDINE AS ADJUVANT TO ROPIVACAINE IN ULTRASOUND GUIDED FOUR IN ONE BLOCK FOR KNEE AND BELOW KNEE SURGERIES

COMPARISION BETWEEN DEXMEDETOMEDINE AND CLONIDINE AS ADJUVANT TO ROPIVACAINE IN ULTRASOUND GUIDED FOUR IN ONE BLOCK FOR KNEE AND BELOW KNEE SURGERIES

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/036092
Enrollment
100
Registered
2021-08-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S820- Fracture of patella Health Condition 2: S821- Fracture of upper end of tibia Health Condition 3: S859- Injury of unspecified blood vesselat lower leg level Health Condition 4: S818- Open wound of lower leg Health Condition 5: S833- Tear of articular cartilage of knee, current Health Condition 6: S999- Unspecified injury of ankle and foot

Interventions

Control Intervention1: 4 in 1 block: 4 in 1 block for lower limb surgeries as analgesia post-operatively Control Intervention2: clonidine dexmedetomidine: clonidine 150 mcg given once during administr

Sponsors

Sanjay Gandhi Institute Of Trauma And Orthopedics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA I to III patients of either sex. 2. Aged between 20 to 60 years and normal BMI 3. Undergoing below knee and knee surgery, like tibia implant, amputation, split skin graft, etc.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of allergic to local anesthetics. 2. Patients with history of mental dysfunction. 3. Patients refusal. 4. Morbid obesity, coagulopathy and significant cardiovascular, respiratory, renal, hepatic or metabolic disease or CNS disorders. 5. Infection at site of procedure.

Design outcomes

Primary

MeasureTime frame
post operative analgesia time periodTimepoint: FOR 48 HOURS—

Secondary

MeasureTime frame
hemodynamical status, adverse effects if anyTimepoint: 48 HOURS—

Countries

India

Contacts

Public ContactDr Amod K S

Sanjay Gandhi Institute of Trauma And Orthopedics

dr.lokesh123@gmail.com9538626747

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026