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To compare effect of administration of own and others blood during abdominal cancer surgery, on inflammatory markers.

To compare and correlate influence of autologous and homologous blood transfusion on interleukin-6 and tumour necrosis factor-α in peri-operative patients undergoing major abdominal oncological surgery- A hospital based observational study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/08/036042
Enrollment
52
Registered
2021-08-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C15-C26- Malignant neoplasms of digestive organs Health Condition 2: C15-C26- Malignant neoplasms of digestive organs

Interventions

Intervention1: Type of Blood Transfusion: Patient undergoing major abdominal oncological surgery, requiring blood transfusion, will receive autologous or homologous blood transfusion depending on the

Sponsors

All India Institute of Medical Sciences Rishikesh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age: 18-65 years 2. Patients posted for major abdominal oncological surgery.

Exclusion criteria

Exclusion criteria: 1. Refusal of patient or relatives. 2. Severe uncontrolled systemic diseases (DM/HTN/CAD/Valvular heart disease/Respiratorydisease/Neuromuscular disorders/Epilepsy). 3. Patients on drugs that could affect immunological function in peri-operative period, like corticosteroid. 4. Bacterial or viral infections; patients with fever before surgery. 5. Auto-immune disease. 6. Pregnancy and lactating women. 7. Patients who have received chemotherapy or radiotherapy within 2 weeks before surgery.

Design outcomes

Primary

MeasureTime frame
TNF-alpha and IL-6 levels at pre-operative (24 hour before surgery) and post-operative time period (24 hours for TNF-alpha, 72 hours for IL-6) between the patients of the two groupsTimepoint: TNF-alpha and IL-6 levels at pre-operative (24 hour before surgery) and post-operative time period (24 hours for TNF-alpha, 72 hours for IL-6) between the patients of the two groups—

Secondary

MeasureTime frame
Haemoglobin, Haematocrit, Total Leucocyte Count.Timepoint: 24 hours pre-operative 24 hours post-operative;Haemorrhage volume, fluid infusion volume and blood transfusion volumeTimepoint: Intra-operative—

Countries

India

Contacts

Public ContactDr Praveen Talawar

All India Institute of Medical Sciences, Rishikesh

praveenrt64@gmail.com9654162941

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026