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Which maintenance intravenous fluid therapy is best in children?

5% Dextrose in Ringerâ??s Lactate versus 5% Dextrose Normal Saline as maintenance intravenous fluid therapy in children- A Randomised Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035924
Enrollment
140
Registered
2021-08-25
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z750- Medical services not available inhome

Interventions

Intervention1: 5% Dextrose in Ringerâ??s lactate: Maintenance IVF will be added and monitored Control Intervention1: 5% Dextrose Normal Saline : Maintenance IVF will be added and monitored

Sponsors

AIIMS Bhubaneswar
Lead Sponsor
Dr Joseph John
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Children who are planned to receive more than 50% of total calculated maintenance intravenous fluids.

Exclusion criteria

Exclusion criteria: Any condition which requires change of maintenance fluids Known case of CKD/ congenital or acquired severe liver disease/ Diabetes insipidus and Diabetes mellitus. Conditions / Procedural fluid therapy in which intravenous fluids were expected to be given for shorter duration than 6 h example any planned procedure like C.T/MRI Scans Conditions causing changes in chloride levels example: Barter syndrome, Congenital Adrenal Hyperplasia etc

Design outcomes

Primary

MeasureTime frame
To calculate the mean difference of hyperchloremia in children receiving 5% Dextrose in Ringerâ??s Lactate versus 5% Dextrose Normal Saline at 24 and 48hrs after start of fluids.Timepoint: To calculate the mean difference of hyperchloremia in children receiving 5% Dextrose in Ringerâ??s Lactate versus 5% Dextrose Normal Saline at 24 and 48hrs after start of fluids.—

Secondary

MeasureTime frame
Proportion of children developing Acute Kidney Injury as defined below in both groupsTimepoint: 24 and 48 hours;Proportion of children developing dyselectrolytemia (hyperchloremia, hypochloremia, hypernatremia, hyponatremia, hyperkalemia and hypokalemia) as defined below in both groupsTimepoint: 24 and 48 hours;Proportion of children developing hyperchloremic metabolic acidosis as defined below in both groupsTimepoint: 24 and 48 hours;To estimate all-cause mortality in both groups.Timepoint: Any time in hospital—

Countries

India

Contacts

Public ContactKavti Hemanth

All India Institute of Medical Sciences, Bhubaneswar

ped_joseph@aiimsbhubaneswar.edu.in08075463299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026