To compare individualized Positive End-Expiratory Pressure with Standard Positive End-Expiratory Pressure on Lung Function in patients undergoing Laparoscopic Surgery

Comparison of Individualized Positive End-Expiratory Pressure with Standard Positive End-Expiratory Pressure on Postoperative Lung Function After Laparoscopic Surgery: A Prospective Randomized Study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035897

Enrollment

Registered

2021-08-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: O- Medical and Surgical Health Condition 3: N29- Other disorders of kidney and ureter in diseases classified elsewhere Health Condition 4: N858- Other specified noninflammatory disorders of uterus

Interventions

Intervention1: After induction of general anaesthesia,for the test group ventilation will be set to V-AC mode and PEEP will be calculated from PV LOOP.: After induction of general anaesthesia,For the

Eligibility

Inclusion criteria

Inclusion criteria: • American Society of Anaesthesiologists (ASA) grading I and II. • Posted electively for laparoscopic surgery

Exclusion criteria

Exclusion criteria: • Preexisting cardiorespiratory, kidney or neuromuscular disease. • Pre-existing lung pathology. • Obese (BMI > 30 kg/m2). • Contraindication to PEEP initiation like increased intracranial pressure or hypotension. • Refusal to participate in study.

Design outcomes

Primary

Measure	Time frame
To compare individualized PEEP with standard PEEP on postoperative PaO2/FiO2 ratio.Timepoint: ABG will be done preoperatively, 1 hour after pneumoperitoneum and 1 hour after extubation.	—

Secondary

Measure	Time frame
1. To compare individualized PEEP with standard PEEP on postoperative pulmonary complications (PPC) which include atelectasis, pneumonia, pneumothorax etcTimepoint: USG chest will be done preoperatively and 1 hour after extubation.;2. To compare the changes in arterial blood gas (ABG) parameters including: (a) PaCO2 (b) PaO2 (c) HCO3 (d) pH Timepoint: ABG will be done preoperatively, 1 hour after pneumoperitoneum and 1 hour after extubation.;3. To compare the changes in parameters of PFT using portable spirometry. (a) FEV1 (b) FEVI/FVC (c) PEF (d) MEF (25-75%) Timepoint: Portable spirometry will be done preoperatively, and 1 hour after extubation.	—

Measure

Time frame

1. To compare individualized PEEP with standard PEEP on postoperative pulmonary complications (PPC) which include atelectasis, pneumonia, pneumothorax etcTimepoint: USG chest will be done preoperatively and 1 hour after extubation.;2. To compare the changes in arterial blood gas (ABG) parameters including: (a) PaCO2 (b) PaO2 (c) HCO3 (d) pH Timepoint: ABG will be done preoperatively, 1 hour after pneumoperitoneum and 1 hour after extubation.;3. To compare the changes in parameters of PFT using portable spirometry. (a) FEV1 (b) FEVI/FVC (c) PEF (d) MEF (25-75%) Timepoint: Portable spirometry will be done preoperatively, and 1 hour after extubation.

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Countries

India

Contacts

Public ContactDr D K Tripathy

AIIMS, RISHIKESH

drdebendra@gmail.com9443278806

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026