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Comparison of gradual return of consciousness and recovey features of sevoflurane and desflurane inhaled anaesthesia drugs in patients after long duration surgeries under general anaesthesia

â??COMPARISON OF DESFLURANE AND SEVOFLURANE FOR EMERGENCE AND RECOVERY CHARACTERISTICS IN ADULT PATIENTS UNDERGOING PROLONGED SURGERIES(more than 4 hrs) UNDER GENERAL ANAESTHESIAâ??

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035860
Enrollment
80
Registered
2021-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I00-I99- Diseases of the circulatory system Health Condition 2: K00-K95- Diseases of the digestive system Health Condition 3: N00-N99- Diseases of the genitourinary system Health Condition 4: M00-M99- Diseases of the musculoskeletal system and connective tissue Health Condition 5: C00-D49- Neoplasms Health Condition 6: E078- Other specified disorders of thyroid Health Condition 7: J988- Other specified respiratory disorders

Interventions

Intervention1: DESFLURANE: Dose: 4-6% (to keep entropy values between 40-60) Route: Inhalational Frequency:Administered continuously through out THE surgery for maintenance of anaesthesia. Newer inhal

Sponsors

Commandant and Principal Command Hospital Air Force
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA physical status Grade I ,II and III 2.Patients undergoing surgeries under General Anaesthesia lasting for more than 4 hours and planned for extubation after surgery

Exclusion criteria

Exclusion criteria: 1.Significant cardiovascular, respiratory, hepatic, renal, neurologic, psychiatric or metabolic disease,Craniotomies and cardiac surgeries 2.ASA Grade > III 3.Any complication leading to deviation from the proposed anaesthesia plan and likely to prevent proper assessment of study variables. 4.Documented allergic reaction to the anaesthetic agent being used. 5.Patient on chronic opioid analgesic or chronic use of alcohol. 6.Patientâ??s refusal to participate in the study

Design outcomes

Primary

MeasureTime frame
To compare Desflurane and Sevoflurane with regards to emergence and recovery characteristics in patients undergoing prolonged surgeries under General Anaesthesia by comparing the â??Modified Aldrete Scoreâ?? between the two groups at 15, 30, 45 and 60 minutes after extubation.Timepoint: By comparing the â??Modified Aldrete Scoreâ?? between the two groups at baseline, 15, 30, 45 and 60 minutes after extubation.—

Secondary

MeasureTime frame
1.Compare time to extubation, spontaneous eye opening and response to verbal commands after switching off the volatile agent. 2.Compare the incidence of laryngospasm, emergence hypertension and postoperative nausea vomiting with use of both the anaesthetic agents. Timepoint: At 15 min, 30 min, 45 min and 60 min after extubation—

Countries

India

Contacts

Public ContactDr Ramakrishna

Command Hospital, Air Force

avanishbhardwaj78@gmail.com9148842423

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026