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Comparison of standard dose ondansetron with dexamethasone and low dose ondansetron with dexamethasone for prevention of nausea and vomiting following laparoscopic cholecystectomy

Comparison of standard dose ondansetron with dexamethasone and low dose ondansetron with dexamethasone for prophylaxis of postoperative nausea and vomiting following laparoscopic cholecystectomy

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035845
Enrollment
110
Registered
2021-08-23
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere

Interventions

Intervention1: Low dose ondansetron with dexamethasone PONV prophylaxis: Low dose ondansetron (50 mcg/kg) with dexamethasone for prophylaxis of postoperative nausea and vomiting following laparoscopic

Sponsors

University College of Medical Sciences and GTB Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I or II undergoing laparoscopic cholecystectomy under General anaesthesia

Exclusion criteria

Exclusion criteria: Pregnant patients and patients having history of significant cardiac, hepatic and renal disease

Design outcomes

Primary

MeasureTime frame
Incidence of PONV between the two groupsTimepoint: At the end of first 24 hrs

Secondary

MeasureTime frame
PONV score at various designated intervals Total rescue antiemetic consumption in 24 hrs NRS pain score Incidence of side effectsTimepoint: PONV score at 0-2 hrs, 2-6 hrs, 6-12 hrs and 12-24 hrs Total consumption of rescue antiemetics at the end of 24 hrs NRS pain score at 0-2 hrs, 2-6 hrs, 6-12 hrs and 12-24 hrs Incidence of side effects at the end of 24 hrs

Countries

India

Contacts

Public ContactDr Janaki K Nandanan

University College of Medical Sciences

janakinandan93@gmail.com8281486751

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026