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To find out which of the drugs; Magnesium sulphate or Clonidine given through nasal route, provide optimal conditions during administration of general anesthesia.

A Comparative study of Magnesium Sulphate and Clonidine nebulizations in attenuation of pressor response to direct laryngoscopy, intubation and post operative sore throat.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035814
Enrollment
90
Registered
2021-08-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulphate nebulisation: Patients will be nebulized with Magnesium Sulphate 50%, 500mg(1ml) diluted to 3ml with normal saline prior to intubation. Total volume being 3ml. Interv

Sponsors

Dr Smitha K S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients who are willing to give written/ informed consent. 2)Patients undergoing elective surgeries under general anaesthesia. 3)Patients belonging to ASA I and II. 4)Patients aged between 18-60 years of age of both genders.

Exclusion criteria

Exclusion criteria: 1)Patients not willing to give written/informed consent. 2)Patients prone to allergies. 3)Patients with prior history of sore throat. 4) Patients with neurological pathologies 5) Patients with cardiovascular instabilities

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the effect of Magnesium sulphate and Clonidine nebulizations on the haemodynamic response upon laryngoscopy and tracheal intubation.Timepoint: 4- 5 hours—

Secondary

MeasureTime frame
To evaluate and compare the effect of Magnesium sulphate and clonidine nebulizations on postoperative sore throat.Timepoint: 24 -36 hours after intubation—

Countries

India

Contacts

Public ContactDr Smitha K S

Bangalore Medical College and Research Institute

smi9685@gmail.com9886935506

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026