Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis
Conditions
Interventions
None listed
Sponsors
University College of Medical Sciences and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients with ASA physical status I or II undergoing laparoscopic cholecystectomy under GA.
Exclusion criteria
Exclusion criteria: Pregnant patients; BMI > 35 kg/m²; Patients having history of significant cardiac, hepatic or renal disease; Patients having nausea or vomiting 24 hours before surgery and/or those receiving any other antiemetics within last 24 hours; Patients on any potential CYP2D6 inhibitors for e.g., beta-adrenergic blocking agents, TCAs, antiarrhythmic 1c class drugs, debrisoquine, codeine or dextromethorphan; & patients with known hypersensitivity to 5HT3 agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation between the specific allele of CYP2D6 between responders and non-respondersTimepoint: baseline sample before surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the total rescue analgesic consumption between the responders and non-responders in 24 hours & The total rescue antiemetic consumption in 24 hours in non-respondersTimepoint: From the blood sample taken at the baseline for gene polymorphism study | — |
Countries
India
Contacts
Public ContactDr Sanjna Tiwari
University College of Medical Sciences
Outcome results
None listed