Health Condition 1: P969- Condition originating in the perinatal period, unspecified
Conditions
Interventions
Intervention1: Vasopressin: Vasopressin to be administered in escalating doses, starting from 0.3mU per kg per minute, increased every 30 minutes, if no response to a maximum of 0.6 mU per kg per minu
Sponsors
Banaras Hindu University
Eligibility
Inclusion criteria
Inclusion criteria: Shock will be defined by the presence of two or more of the following criteria: 1. Heart rate above 180 per minute 2. Capillary refill time more than 3 seconds 3. Skin mottling 4. Cold extremities 5. Feeble peripheral pulses 6. Altered sensorium 7. Hypotension as per nomogram 8. Oliguria 9. Blood lactate above 4 mmol per litre
Exclusion criteria
Exclusion criteria: 1. Life threatening congenital malformations 2. Considered nonviable by the treating clinician 3. Prior exposure to inotropes 4. Failure to obtain consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment failure will be defined as persistence of shock after 2 hours of starting vasopressors in escalating dosagesTimepoint: 2 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in parameters at various time points during hospitalization: 1. Heart rate 2. Blood pressure, systolic, disatolic, mean 3. Oxygen saturation 4. Blood lactate 5 Arterial blood gases 6. Blood glucose 7. Serum sodium 8. Blood urea and serum creatinine 9. Respiratory support 10. Vasoactive inotropic score 11. Hospital mortality 12. Duration of hospital stayTimepoint: 1. For secondary outcome variables 1 to 10, during acute phase of illness 2. For hospital mortality, during birth hospitalization. 3. Duration of hospital stay during birth hospitalization | — |
Countries
India
Contacts
Public ContactShikhar Garg
Banaras Hindu University
Outcome results
None listed