Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: INJ. PANTOPRAZOLE: Patients in the study arm will receive Early Enteral Nutrition ( within 24 hours of PICU admission) with Inj. Pantoprazole 1 mg/kg diluted in Normal saline once a day
Sponsors
Dr ANANYA KAVILAPURAPU
Eligibility
Inclusion criteria
Inclusion criteria: - Shock/hemodynamic instability - Invasive or non-invasive mechanical ventilation expected to last > 24 hours - Coagulopathy (platelet 1.5 or prothrombin time (PT) > 20 s or APTT > 50s) - Treatment with anticoagulant drugs - Chronic liver disease (portal hypertension, cirrhosis, variceal bleeding or hepatic encephalopathy)
Exclusion criteria
Exclusion criteria: - Contraindications to PPIs (including intolerance of PPIs) - Current daily treatment with a PPI and/or a H2RA - GI bleeding of any origin during current hospital admission - Burn injury - Chronic steroid therapy - Closed head injury or increased intracranial pressure - History of partial or complete gastrectomy - Known peptic ulcer disease - Not willing to participate in the study - Moribund patients with anticipated survival
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinically Significant Gastrointestinal BleedingTimepoint: Reaching full Enteral Nutrition Discharge from PICU 28 days of PICU stay Death | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. 28-day all-cause mortality 2. Length of PICU and hospital stay 3. Duration of mechanical ventilation 4. Incidence of Ventilator Associated/nosocomial Pneumonia 5. Incidence of Clostridium difficile infection 6. Incidence of serious adverse events 7. Organ dysfunction scores (PELOD, SOFA) Timepoint: Reaching full Enteral Nutrition Discharge from PICU 28 days of PICU stay Death | — |
Countries
India
Contacts
Public ContactDr ANANYA KAVILAPURAPU
st. Johns medical College and Hospital
Outcome results
None listed