A clinical trial to study the effects of two drugs, dexmedetomidine , a drug used in tratment of raised blood pressure and for sedation and fentanyl, a drug used for pain relief and for sedation in patients undergoing spine surgery.

A comparative study of the effect of dexmedetomidine and fentanyl on haemodynamic response in patients undergoing lumbar spine surgery under general anaesthesia - a randomized controlled study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035769

Enrollment

Registered

2021-08-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: Loading dose 0.5 Âµg /kg over 10 min before induction of anaesthesia and 0.25 Âµg / kg / hrs. infusion during intraoperative period Control Intervention1: Fentanyl: Loa

Eligibility

Inclusion criteria

Inclusion criteria: 1.Consent to participate in study 2.American Society of Anaesthesiologist Grade I&II. 3.Patients undergoing lumbar spine surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Patients with disorder of cardiovascular, hepatic, renal or neuromuscular systems. 2.Patients with uncontrolled systemic diseases such as diabetes mellitus, hypertension, chronic obstructive lung disease9. 3.Patients on calcium channel blockers, beta blockers, chronic use of opioids. •Patients with BMI >35.10 •Patients receiving drugs known to interact with study drugs.

Design outcomes

Primary

Measure	Time frame
Dexmedetomide is more effective than fentanyl in maintaining heamodynamic changes during lumbar spine surgery under general anaesthesiaTimepoint: 24 weeks	—

Secondary

Measure	Time frame
Side effects and complications are minimal with both the drugsTimepoint: 24 weeks	—

Countries

India

Contacts

Public ContactDr Rakesh D R

Gajra raja medical college

drjagrawal@gmail.com9300009942

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026