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Evaluation of effectiveness of preoperative Dexmedetomidine nebulization vs Lignocaine nebulization on blood pressure and heart rate changes to laryngoscopy and tracheal intubation

Evaluation of efficacy of preoperative Dexmedetomidine nebulization vs Lignocaine nebulization on hemodynamic changes to laryngoscopy and tracheal intubation - a prospective randomized clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035734
Enrollment
60
Registered
2021-08-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Preoperative Dexmedetomidine nebulization: Preoperative Dexmedetomidine nebulization in dose of 1microgram per kg with 4ml normal saline just 30 minutes prior giving anesthesia to blunt

Sponsors

Urvisha Mendpara
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for elective surgery under general anesthesia requiring endotracheal intubation ASA grade 1 & 2

Exclusion criteria

Exclusion criteria: Patient refusal, nasal deformity or nasal blockade, pregnancy , obesity, known or anticipated difficult intubation, requiring more than 2 attempts of intubation or more than 20 sec for laryngoscopy, hypertensive patients, allergic to Dexmedetomidine or Lignocaine

Design outcomes

Primary

MeasureTime frame
Reduction in heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure in response to laryngoscopy and tracheal intubationTimepoint: Observe heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure at time of laryngoscopy , 1 min ,3 min, 5 min and 10 min after that

Secondary

MeasureTime frame
To observe effects on rate pressure product or side effects if anyTimepoint: At time of laryngoscopy, 1min ,3min ,5min and 10 min after that

Countries

India

Contacts

Public ContactDr Mamta Patel

Government Medical College and SSG Hospital, Vadodara

mgpatel111@yahoo.com9825453024

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026