A CLINICAL TRAIL TO STUDY THE ANALGESIC EFFICACY OF ORAL CLONIDINE VS INTRATHECAL CLONIDINE WHEN ADDED AS AN ADJUVANT TO 0.5% HYPERBARIC BUPIVACAINE IN CESAREAN SECTION.

TO ASSESS THE ANALGESIC EFFICACY OF ORAL CLONIDINE VS INTRATHECAL CLONIDINE ADDED AS AN ADJUVANT TO 0.5% HYPERBARIC BUPIVACAINE IN CESAREAN SECTION --- A PROSPECTIVE RANDOMIZED DOUBLE BLIND CONTROLLED TRIAL.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035730

Enrollment

Registered

2021-08-17

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O998- Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

Interventions

Intervention1: Intrathecal clonidine as an adjuvant for 0.5% Hyperbaric bupivacaine: 45 Âµg of clonidine intrathecally +0.5 % Hyperbaric bupivacaine 2cc(10mg) Control Intervention1: Oral clonidine as

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status â? and â?¡. Age 18-31 years. Singleton pregnancy Informed, written and valid consent.

Exclusion criteria

Exclusion criteria: Obstetric complications such as Placenta previa, Abruptio placenta and Preeclampsia. Spinal deformity such as kyphoscoliosis. BMI greater than 35kg/m2. Height less than 150 cm or greater than180 cm. Women with Hypertensive disorders,Cardiovascular disorders,Deep vein thrombosis. Allergy to study drugs.

Design outcomes

Primary

Measure	Time frame
To determine the duration of analgesia.Timepoint: Duration of analgesia is assessed every 15 minutes from onset of sensory block to first request for rescue analgesic or VAS score 4 or more.	—

Secondary

Measure	Time frame
Onset and duration of sensory block. Onset and duration of motor block. Hemodynamic changes Fetal well being. Timepoint: Assessed every 15 minutes from onset of sensory block to regression of dermatome of two segments. Degree of motor block checked every 5 mins for first 30mins. Pulse, Blood pressure (mean), were recorded at 0 minute, 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 60 minutes after administration of Spinal anesthesia. Fetal well being is assessed by APGAR scores at one minute and five minutes after birth.	—

Measure

Time frame

Onset and duration of sensory block. Onset and duration of motor block. Hemodynamic changes Fetal well being. Timepoint: Assessed every 15 minutes from onset of sensory block to regression of dermatome of two segments. Degree of motor block checked every 5 mins for first 30mins. Pulse, Blood pressure (mean), were recorded at 0 minute, 5 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 60 minutes after administration of Spinal anesthesia. Fetal well being is assessed by APGAR scores at one minute and five minutes after birth.

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Countries

India

Contacts

Public ContactDr Jyothi B

Karnataka institute of medical sciences

dr.jyothib1@gmail.com9886187056

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026