Effect of phenylephrine drug on blood loss after cesarean section

Effect of phenylephrine infusion on postpartum blood loss during cesarean delivery: A Placebo controlled, randomized clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035713

Enrollment

106

Registered

2021-08-17

Start date

Unknown

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O60-O77- Complications of labor and delivery

Interventions

Intervention1: PHENYLEPHRINE: Continuous infusion at the rate of 60 ml/hour (50 microgram/minute) during the intraoperative period Control Intervention1: PLACEBO(NORMAL SALINE): Continuous infusion at

Eligibility

Inclusion criteria

Inclusion criteria: Women more than 18 years of age undergoing elective or emergency cesarean delivery under spinal anesthesia

Exclusion criteria

Exclusion criteria: 1.Preeclampsia, pregnancy-induced hypertension 2.Patient with heart disease 3.Any grade of placenta previa and placenta abruption 4.Patient with liver dysfunction, coagulopathy 5.Patients undergoing elective or emergency cesarean delivery under general anesthesia

Design outcomes

Primary

Measure	Time frame
To assess the effect of phenylephrine infusion on post-partum blood loss in patients undergoing cesar-ean delivery under spinal anaesthesiaTimepoint: post-partum blood loss will be assessed after the skin closure(end op)	—

Secondary

Measure	Time frame
To assess the effect of phenylephrine infusion in the incidence of intra operative hypotension in patients undergoing cesarean delivery under spinal anaesthesiaTimepoint: intra operative hypotension will be recorded during the operation;To assess the effect of phenylephrine on a composite of neonatal outcome, APGAR score, Neonatal intensive care unit(NICU) admission and umbilical arterial pH.Timepoint: APGAR score, Neonatal intensive care unit(NICU) admission and umbilical arterial pH will be assessed after the skin closure(end op);To assess the effect of phenylephrine on intra op-erative maternal satisfaction in patients undergoing cesarean delivery under spinal anaesthesiaTimepoint: intra op-erative maternal satisfaction is assessed within 6 hours after the surgery ends	—

Measure

Time frame

To assess the effect of phenylephrine infusion in the incidence of intra operative hypotension in patients undergoing cesarean delivery under spinal anaesthesiaTimepoint: intra operative hypotension will be recorded during the operation;To assess the effect of phenylephrine on a composite of neonatal outcome, APGAR score, Neonatal intensive care unit(NICU) admission and umbilical arterial pH.Timepoint: APGAR score, Neonatal intensive care unit(NICU) admission and umbilical arterial pH will be assessed after the skin closure(end op);To assess the effect of phenylephrine on intra op-erative maternal satisfaction in patients undergoing cesarean delivery under spinal anaesthesiaTimepoint: intra op-erative maternal satisfaction is assessed within 6 hours after the surgery ends

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Countries

India

Contacts

Public ContactDr SANJEETH R

Jawaharlal Institute of Postgraduate Medical Education and Research

jipmermishra@gmail.com9344668104

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026