effects of use of pre operattive l theanine and gaba

COMPARISON OF THE EFFECTS OF TWO AMINO ACIDS: GAMMA-AMINOBUTYRIC ACID AND L-THEANINE ON SEDATION, ANXIETY AND COGNITION IN PRE-OPERATIVE SURGICAL PATIENTS-A RANDOMISED CONTROLLED TRIAL - CTGLSAC

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035694

Enrollment

168

Registered

2021-08-16

Start date

Unknown

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Giving l theanine 200mg and gaba 500 mg 60 minutes before induction time: Comparison of l thenaine 200 mg and gaba 500mg in cognition,sedation and anxiety in preoperative surgical pati

Eligibility

Inclusion criteria

Inclusion criteria: Physical status ASA 1 and 2 Age 18-55 years Body weight 50-70 kgs Planned for major surgery procedures under general Anesthesia Giving informed consent

Exclusion criteria

Exclusion criteria: BP less than 110mmhg systolic and less than 60 mmhg diastolic Mentally impaired History of psychiatric disorders and on antipsychotics Sleep disorders History of liver and kidney disorders Pregnant and lactating womens

Design outcomes

Primary

Measure	Time frame
To study the effects of l theanine and gaba on anxiety, sedation and cognition in preoperative patients posted for major elective surgeries under general anesthesia To compare the effects of l theanine and gaba with alprazolam on anxiety,sedation and cognition in preoperative patients posted for major elective surgeries under general anesthesiaTimepoint: 1 year	—

Secondary

Measure	Time frame
To find out any adverse effects to l theanine and gabaTimepoint: For 1 year 6 months period	—

Countries

India

Contacts

Public ContactDR MADHURI S KURDI

KARNATAKA INSTITUTE OF MEDICAL SCIENCES HUBBALLI

drmadhuri_kurdi@yahoo.com9449590556

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026