Health Condition 1: S065- Traumatic subdural hemorrhage
Conditions
Interventions
Intervention1: Propranolol: Patients of moderate and severe TBI who meet eligibility criteria will be randomized and those in test group will be given beta-blocker drug (propanolol) immediately after
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients who present within 24 hours of moderate and severe traumatic brain injury who have: a)Glasgow Coma Scale (GCS) score of b)Age: 18 to 60 years
Exclusion criteria
Exclusion criteria: • Pre-existing condition o Heart disease o Cardiac dysrhythmia o Allergy to study drugs • Brain-related o Penetrating brain injury o Pre-existing brain dysfunction • Physiologic o Spinal cord injury o Myocardial injury o Severe liver disease o Current use of β-blocker and/or α2-agonist o Withdrawal of care expected in 48 h • Demographic o Prisoners o Pregnant women o Unable to follow-up through final visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the efficacy of beta blockers in reducing the mortality of hospitalized severe traumatic brain injury (TBI) patientsTimepoint: AT the time of discharge from hospital and 3 and 6 months after trauma. | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ To assess the improvement in dysautonomia clinically.Timepoint: 6 months;â?¢ To determine the efficacy of beta blockers in improving the functional outcomes and the quality of life of moderate and severe TBI patient at 6 months post injury Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactKanwaljeet Garg
All India Institute of Medical Sciences
Outcome results
None listed