A clinical study to compare the the sedative drug combination dexmedetomidine plus ketamine and midazolam plus ketamine on patients undergoing short surgical procedures.

Comparative evaluation of the combination of intravenous Ketamine Hydrochloride plus Dexmedetomidine Hydrochloride and Ketamine Hydrochloride plus Midazolam Hydrochloride in procedural sedation for short surgical procedures- A randomized controlled study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035523

Enrollment

100

Registered

2021-08-09

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N939- Abnormal uterine and vaginal bleeding, unspecified Health Condition 2: K929- Disease of digestive system, unspecified Health Condition 3: N359- Urethral stricture, unspecified

Interventions

Intervention1: Dexmedetomidine plus Ketamine: Infusion of intravenous Dexmedetomidine 0.1 mcg/kg in 100 ml normal saline, followed by intravenous ketamine 1 mg/kg. Control Intervention1: Ketamine and

Eligibility

Inclusion criteria

Inclusion criteria: Consent to participate in study ASA physical Grade 1 and 2 Patients undergoing short surgical procedures

Exclusion criteria

Exclusion criteria: Patients refusal. Pregnancy and lactating women. History of any significant pulmonary, cardiovascular, neurological, hepatoreanal or metabolic disease. chronic use or addiction to opiates or sedatives.

Design outcomes

Primary

Measure	Time frame
we expect that dexmedetomidine plus ketamine will provide adequate depth of anaesthesia and more stable hemodynamic variables.Timepoint: 20 weeks	—

Secondary

Measure	Time frame
We expect dexmedetomidine plus ketamine to provide less incidence of postoperative complicationsTimepoint: 20 weeks	—

Countries

India

Contacts

Public ContactDr Dilip Kothari

GR Medical College, Gwalior

drdilip_kothari@yahoo.co.in9827217327

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026