To study the effect of two different doses of oral melatonin on post-operative cognitive dysfunction in elderly patients after surgery under regional anesthesia

A comparison of the effect of two different doses of oral melatonin on post-operative cognitive dysfunction in elderly patients after surgery under regional anaesthesia : A randomized controlled double blinded study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/08/035467

Enrollment

120

Registered

2021-08-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G968- Other specified disorders of central nervous system

Interventions

Intervention1: 1 hrs: HEMODYANMICS STABILITY Control Intervention1: PLACEBO DRUG 5-10 MG ORAL MELATONIN 3 GROUPS: HEMODYNAMICS STABILITY CHANGE IN POCD SCORE Control Intervention2: Placebo drug(multi

Eligibility

Inclusion criteria

Inclusion criteria: patients given written informed consent will be taken age 60 years male and female All patients under regional anaesthesia ASA grade I, II and III

Exclusion criteria

Exclusion criteria: any comorbidities dementia not given consent age >60 years

Design outcomes

Primary

Measure	Time frame
Mini mental state examination score, subjective sleep quality and general well beingTimepoint: Pre operatively, at day 1, day3,day7 and 3months after surgery	—

Secondary

Measure	Time frame
changes in POCD scoreTimepoint: 1-2hrs	—

Countries

India

Contacts

Public ContactMonica Kohli

King Georges medical University

monica_kohli@rediffmail.com9839041228

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026