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A clinical trial to study the effect of addition of drugs Dexmedetomidine and Dexamethasone to regional nerve block of upper extremity surgeries

COMPARISON BETWEEN DEXMEDETOMIDINE AND DEXAMETHASONE AS ADJUVANT TO ROPIVACAINE IN ULTRASOUND GUIDED SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035448
Enrollment
90
Registered
2021-08-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue

Interventions

Intervention1: Solution 1: Inj. Ropivacaine 0.75% 10 ml with Inj. Dexmedetomidine 30 mcg, diluted to a total of 30 ml Intervention2: Solution 2: Inj. Ropivacaine 0.75% 10 ml with Inj. Dexamethasone 30

Sponsors

Jubilee Mission Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age from 18 years to 65 years 2. American Society of Anaesthesiologists (ASA) physical status class I and II 3. Patients scheduled for upper limb surgeries at the level of mid shaft of humerus and below

Exclusion criteria

Exclusion criteria: 1. Patient refusal for study participation 2. Local infection at injection site 3. Presence of any coagulopathies, bleeding disorders or patients on anticoagulants 4. Presence of neurological deficits, peripheral neuropathies, myopathies or chronic pain in the operating limb 5. Patients with known allergy to local anaesthetics or to any of the study drugs to be used 6. Patients with baseline bradycardia or on beta blockers/alpha agonists 7. Hemodynamically compromised patients 8. Alcoholic/psychiatric/uncooperative patients 9. Pregnant and breast-feeding mothers 10.Patients with diabetes, hepatic/renal or cardiopulmonary disorders 11.Morbid obesity

Design outcomes

Primary

MeasureTime frame
Onset and duration of sensory and motor blockadeTimepoint: Onset of sensory and motor blockade will be assessed every 3 minutes after the completion of injection upto 60 minutes. Duration of sensory and motor blockade will be assessed in the first 24 hours after block.

Secondary

MeasureTime frame
1. Duration of analgesia 2. Hemodynamic parameters during surgeryTimepoint: Duration of analgesia is the time from commencement of block to patientâ??s first request for rescue analgesic in the first 24 hours. Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation and respiratory rate will be recorded for first 6 hours.

Countries

India

Contacts

Public ContactDr Sugatha Prakash

Jubilee Mission Medical College and Research Institute

sugatha234@gmail.com9633397003

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026