Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intravenous Dexmedetomidine: Intravenous adjuvant to spinal anesthesia with sedative, hypnotic, analgesic, alpha-2 agonist agent.
Control Intervention1: Not Applicable: Not Applicable
Sponsors
KPC Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients of American Society of Anesthesiologists(ASA) Grades I and II. Patients undergoing elective lower limb surgery with spinal anesthesia.
Exclusion criteria
Exclusion criteria: Patients outside age group of 18-65 years. Patients allergic to dexmedetomidine. Patients of ASA Grades III, IV, V, VI. Significant cardiovascular, pulmonary, hepatic or renal impairment. Pregnant patients. Obese patients (BMI more than 30 kg/m2). Patients on �²-blocker and Ca2+ channel blocker. Contraindications for regional anesthesia including coagulopathy, or local skin infection. Patients preferring general anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset of block including autonomic, sensory and motor block Duration of block Perioperative hemodynamic adverse effects Timepoint: Sensory blockade will be evaluated by two-dermatomal regression from the maximum level, and regression to S1 level will be noted at 1, 2, 5 min after giving spinal anesthesia and then at every 5 min till 30 min and then at every 15 min till recovery of block to S1 level. Motor blockade will be assessed by modified Bromage scale at 1, 2, and 5 min after giving spinal anesthesia, then at every 5 min till 30 min and then every 15 min till full recovery of motor level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation and post-operative analgesia by Visual Analogue ScaleTimepoint: Ramsay level of sedation scale will be used to assess sedation at 1, 2, and 5 min after giving spinal anesthesia, then at every 5 min till 30 min and then every 15 min till discharge from postanesthesia care unit. Postoperative pain intensity will be assessed using a 10-point visual analog scale (VAS) for 24 hours. Postoperative nausea, vomiting, and shivering will be observed till the discharge of the patient. | — |
Countries
India
Contacts
Public ContactDR ARNAB RAY
KPC Medical College and Hospital
Outcome results
None listed