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comparing two drugs in head injury patients undergoing surgery

Comparison of Dexmedetomidine vs Fentanyl based Total Intravenous Anaesthesia Technique on Requirement of propofol, Brain relaxation, Intracranial pressure, Neuronal injury, and Hemodynamics in patients with acute traumatic subdural hematoma undergoing emergency craniotomy: A Randomized Control Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/08/035323
Enrollment
100
Registered
2021-08-02
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: dexmedetomidine infusion: Dexmedetomidine bolus 1mcg/kg followed by 0.5mcg/kg/hr in the intraoperative period Control Intervention1: fentanyl infusion: fentanyl infusion 1mcg/kg bolus f

Sponsors

Intramural grant from institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients 18 â?? 60 years ofage ASA1-3 Emergency SDH evacuation GCS <13

Exclusion criteria

Exclusion criteria: 1.Allergy to medications 2.Pregnant and nursing women 3.Type 2 heart block 4.Heart rate Hemodynamically unstable patients (Systolic blood pressure less than 90mmHg)

Design outcomes

Primary

MeasureTime frame
To compare the mean propofol consumption between dexmedetomidine and fentanyl based TIVA in patients with acute traumatic subdural hematoma undergoing craniotomy for evacuation of subdural hematomaTimepoint: Mean propofol consumption at 60th min, 120th min, 180th min, 240th min, 300th min, 360th minute after the starting of surgery.—

Secondary

MeasureTime frame
Comparison of serum S100β levels between the groups at two time points (pre induction and end of surgery)Timepoint: sample will be collected before induction and one more sample will be collected at the end of the surgery and will be analysed—

Countries

India

Contacts

Public ContactDr Prasanna Bidkar

JIPMER

drprasannabidkar@gmail.com9442706168

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026