FindTrial
Sign In

CLINICAL TRIAL TO STUDY ANTIEMETIC EFFECT OF PROPOFOL AND ONDANSETRON IN PATIENTS UNDERGOING OPEN ABDOMINAL SURGERY

COMPARISON BETWEEN INTRAVENOUS ONDANSETRON VERSUS PROPOFOL FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING OPEN ABDOMINAL SURGERY UNDER GENERAL ANAESTHESIA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/035293
Enrollment
70
Registered
2021-07-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: INTRAVENOUS PROPOFOL: IV PROPOFOL GIVEN 20 MINUTES BEFORE SKIN CLOSURE FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING Control Intervention1: INTRAVENOUS ONDANSETRON: IV ONDANSETRON

Sponsors

DR RASHMI GUPTA
Lead Sponsor
DR RAJENDRA KUMAR SOLANKI
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA CATEGORY 1 AND 2 SURGERY TYPE - ELECTIVE OPEN ABDOMINAL SURGERY ANAESTHESIA TYPE- GENERAL ANAESTHESIA

Exclusion criteria

Exclusion criteria: REFUSE TO GIVE WRITTEN INFORMED CONSENT ANAESTHESIA INDUCED AND MAINTAINED WITH PROPOFOL (IF NEEDED) HAEMODYNAMICALLY UNSTABLE ( IN SHOCK/VASOPRESSOR SUPPORT) POSITIVE HISTORY OF DRUG ALLERGY/ALLERGY TO STUDY DRUGS PATIENT ON STEROID/OPIOIDS THERAPY,OR ON MEDICATIONS CAUSING NAUSEA/VOMITING PREGNANT AND LACTATING PATIENT PATIENT WITH HISTORY OF MOTION SICKNESS

Design outcomes

Primary

MeasureTime frame
to compare the antiemetic effect of IV ondansetron versus IV propofol for prevention of postoperative nausea and vomiting in patients undergoing open abdominal surgery under general anaesthesiaTimepoint: NEED OF TOTAL MEAN RESCUE ANTIEMETIC REQUIREMENT FOR 24 HOURS POSTOPERATIVELY IN BOTH GROUPS—

Secondary

MeasureTime frame
Mean PONV score and severity in first 24 after surgery Mean time to need for first rescue antiemetic, Mean haemodynamic parameters during 24 hours postoperatively, Mean sedation score in PACU after one hour of completion of surgery, Mean time to stay in the recovery room after extubation with help of aldrete score, Side effects and complication (if any). Timepoint: MEAN PONV SCORE AND SEVERITY FOR 24 HOURS POSTOPERATIVELY—

Countries

India

Contacts

Public ContactDR RAJENDRA KUMAR SOLANKI

DR.S.N.MEDICAL COLLEGE, JODHPUR

drrashmigupta1995.rg@gmail.com09636938666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026