To compare the effect of an anaesthesia technique on two different types of local anaesthetic drugs given for spinal anaesthesia in patients undergoing lower abdominal and lower limb surgeries

To compare the effect of epidural volume expansion on intrathecal hyperbaric bupivacaine and isobaric bupivacaine in patients undergoing lower abdominal and lower limb surgeries - A prospective randomised study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/035278

Enrollment

Registered

2021-07-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N81- Female genital prolapse Health Condition 2: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Isobaric Bupivacaine: 0.5% 10mg intrathecally followed by 7ml of 0.9% normal saline Control Intervention1: Hyperbaric bupivacaine: 0.5% 10mg intrathecally followed by 7ml of 0.9% normal

Eligibility

Inclusion criteria

Inclusion criteria: 1)American society of anesthesiologists(ASA) physical status classification 1 and 2 2)Scheduled for elective lower abdominal and lower limb surgery under regional anesthesia 3)Patients with valid informed consent

Exclusion criteria

Exclusion criteria: 1)Patient refusal for reginal anesthesia 2)Intrinsic or idiopathic coagulopathy 3)Skin or soft tissue infection at proposed site of needle insertion 4)Preexisting neurological disease like lower extremity neuropathy 5)Patients with spinal deformities 6)Severe hypovolemia 7)Emergency lower limb surgeries 8)Patients with known allergy to study drugs

Design outcomes

Primary

Measure	Time frame
The onset of sensory block to T10 levelTimepoint: Sensory level checked at 5 minutes,10 minutes and every 30 minutes there after	—

Secondary

Measure	Time frame
Degree of motor blockade achievedTimepoint: Degree of motor blockade checked every 5 minutes for first 30 minutes;Requirement of rescue analgesiaTimepoint: If used in first 24 hours;Time taken for two segment regression of sensory blockadeTimepoint: Sensory level checked every 30 minutes	—

Countries

India

Contacts

Public ContactDr Pushpavathi S H

karnataka institute of medical sciences

pushpadrture@rediffmail.com9448251597

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026