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To compare the ability to prevent Nausea and Vomiting by Dexmedetomidine versus its combination with Dexamethasone after surgery of the abdomen in adult patients

Comparison of intravenous Dexmedetomidine with Dexmedetomidine-Dexamethasone combination for prevention of Post-Operative Nausea and Vomiting in adult patients after abdominal surgeries

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/07/035276
Enrollment
75
Registered
2021-07-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R112- Nausea with vomiting, unspecified

Interventions

Intervention1: Dexmedetomidine: Intravenous infusion of Dexmedetomidine 0.5 mcg/kg (diluted to 10 mL with Normal Saline) over 10 minutes just before incision Control Intervention1: Normal Saline: IV N

Sponsors

Department of Anaesthesia and Intensive Care
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I/II. Patients undergoing abdominal surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patients with previous history of post-operative nausea and vomiting, abdominal surgery, cardiovascular or cerebrovascular comorbidities, diabetes mellitus. Patients with history of treatment with antiemetic or glucocorticoids. Patients with BMI >30 kg/m2.

Design outcomes

Secondary

MeasureTime frame
PainTimepoint: End of surgery 1 hour post-op 3 hour post-op 6 hour post-op 9 hour post-op 12 hour post-op 24 hour post-op;SedationTimepoint: End of surgery 1 hour post-op 3 hour post-op 6 hour post-op 9 hour post-op 12 hour post-op 24 hour post-op—

Primary

MeasureTime frame
Nausea Incidence and frequency of vomitingTimepoint: End of surgery 1 hour post-op 3 hour post-op 6 hour post-op 9 hour post-op 12 hour post-op 24 hour post-op—

Countries

India

Contacts

Public ContactTanmay Yadav

Vardhman Mahavir Medical College and Safdarjung Hospital

tanmayadav@icloud.com9818829408

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026