Comparison oftwo drugs that help in relief of post operative pain in patients undergoing spine surgeries under General Anesthesia, where ketamine and lignocaine injection is used to reduce pain.

Comparison of the effect of intraoperative ketamine and lignocaine infusion on early post operative pain relief in patients undergoing spine surgeries under general anesthesia.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/07/035237

Enrollment

Registered

2021-07-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: I10- Essential (primary) hypertension Health Condition 3: G958- Other specified diseases of spinalcord

Interventions

Control Intervention1: Iv ketamine vs lignocaine: Comparison of post operative pain in patie undergoing spine surgeries, with iv ketamine vs iv lignocaine Control Intervention2: Iv Lignocaine: Immedia

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA physical status 1 and 2 undergoing multilevel spine surgeries with or without instrumentation.

Exclusion criteria

Exclusion criteria: 1.Subjects with pshychiatric illness, known allergy and contraindication to ketamine and lignocaine. 2. history of drug abuse and dependence to opioids and alcohol. 3.BMI >30kg/m2 4.Patients with chronic pain disorder. 5.Liver Cirrhosis (SGOT/SGPT >2 times normal) and chronic renal failure (s.creatinine >2mg/dl) 6.Severe cardio vascular disease 7.Epilepsy and other neurological disorder.

Design outcomes

Primary

Measure	Time frame
To measure and compare visual analogue score (VAS) in the post anesthesia care unit (PACU) at rest and with movement in both the groups.Timepoint: Immediately on arrival to PACU and at every 15mins interval for first hour i.e 15mins, 30mins, 45mins and 60mins.	—

Secondary

Measure	Time frame
To evaluate and compare analgesic requirement, haemodynamic effects like bradycardia, tachycardia, hypertension and occurance of adverse effects if any due to lignocaine and ketamine use.Timepoint: Baseline, post induction, post intubation, post positioning for surgery, 15mins, 30mins, 45mins, 60mins, 75mins, 90mins, post extubation, 5mins post extubation.	—

Countries

India

Contacts

Public ContactDr Yatish B

M S Ramaiah Medical College

yatishseeni@yahoo.co.in9886197658

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026