Health Condition 1: F42- Obsessive-compulsive disorder
Conditions
Interventions
Intervention1: Intervention:Injection Ketamine: 6 infusions of Injection Ketamine 0.5 mg/kg body weight over 2 weeks.
Control Intervention1: Comparator Agent: Injection MIdazolam: 6 infusions of Injec
Sponsors
Central Institute of Psychiatry CIP
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of either sex, aged between 21-50 years. 2. Inpatients fulfilling ICD 10-DCR diagnostic criteria for OCD but are treatment non-responders. 3. Patients giving written informed consent.
Exclusion criteria
Exclusion criteria: 1. Any other major co-morbid psychiatric diagnoses (except depression and mild to moderate anxiety) and substance dependence excluding nicotine & caffeine. 2. Presence of an acute/unstable medical or neurological condition. 3. Pregnancy or lactation. 4. Childhood onset OCD (age at onset
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score on the Dimensional Yale Brown Obsessive Compulsive Scale(DY-BOCS) Plasma BDNF levels as measured by Sandwich ELISA methodTimepoint: DY-BOCS-1 hour before and 1 hour, 4 hours and 24 hours after each infusion for 2 weeks and 4 weeeks after last infusion. Plasma BDNF-1 day before 1sy infusion, after 3rd infusion or 1st week and after 6th infusion or 2nd week. | — |
Secondary
| Measure | Time frame |
|---|---|
| Score on the Montgomery Asberg Depression Rating scale (MADRS). Score on the Hamilton Anxiety Rating Scale(HAM-A) Score on the Clinician-Administered Dissociative States Scale(CADSS), and Score on the Systemic Assessment for Treatment Emergent Events(SAFTEE)Timepoint: 1 hour before and 1 hour, 4 hours and 24 hours after each infusion for 2 weeks and 4 weeeks after last infusion. | — |
Countries
India
Contacts
Public ContactDr Varun S Mehta
Central Institute of Psychiatry
Outcome results
None listed