Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Nebulization with dexmedetomidine: Prior to anesthesia induction subjects in the dexmedetomidine group shall be nebulised with 50 mcg of dexmedetomidine mixed with 4 ml saline.
Interven
Sponsors
Shri Ram Murti Smarak Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18-60 years of either sex, ASA physical status I/II, Duration surgical procedures Undergoing short (parotidectomy, thyroidectomy, dental extractions, laparoscopic cholecystectomy) extending up to 2 hours will be enrolled in the study.
Exclusion criteria
Exclusion criteria: Patient refusal, Hypersensitivity to the drugs being evaluated, History of pre-operative sore throat, Upper respiratory tract infection, Pregnancy, Chronic obstructive pulmonary disease/ Asthmatic patients, Cardiac patients, Hepatic/renal disease, Mallampatti grade
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Examine the effectiveness of dexmedetomidine nebulisation in attenuating Post Operative Sore Throat in adult patients undergoing General endotracheal tube anaesthesia, when compared with clonidine and conventional saline NebulizationTimepoint: At 0,1, 2, 4, 6, 8, 12 and 24h post-extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side-effects such as cough, dry mouth, post-operative nausea and vomiting (PONV), hallucinations, respiratory depression and haemodynamic instability, intra-operatively and post-operatively.Timepoint: Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MABP) will be monitored at pre-nebulisation, pre-induction, intra-operatively at every 15 minutes duration till end of surgery and at 0,1, 2, 4, 6, 8, 12 and 24 h post-extubating. Side effects At 0,1, 2, 4, 6, 8, 12 and 24h post-extubation | — |
Countries
India
Contacts
Public ContactDr Akhilesh Pahade
Shri Ram Murti Smarak Institute of Medical Sciences
Outcome results
None listed