Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery Health Condition 2: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified
Conditions
Interventions
Intervention1: milrinone and levosimendan: Twenty four patients will be allocated randomly into two groups to receive either milrinone, 50 �µg/kg bolus intra operatively followed by infusion at a ra
Sponsors
cmc Vellore fluid research grand
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients, between 40 and 70 years 2. Both sexes 3. Impaired left ventricular function (Ejection fraction � 40%), 4. Mean pulmonary artery pressure between 25-35 mmHg, 5. New York Heart Association (NYHA III & IV) 6. Undergoing elective On-Pump Coronary Artery Bypass Graft surgery
Exclusion criteria
Exclusion criteria: 1. Geriatric patients (age over 70 years). 2. Patients with end-organ failure (renal, liver). 3. Perioperative surgical complications unrelated to the study (accidental surgical trauma to a nearby organ or massive blood loss defined as blood loss exceeding circulating blood volume within a 24-hour period due to surgical insult). 4. Associated mitral or aortic valve disease. 5. Preoperative requirement of inotropes or mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Comparison of pre-operative and post-operative CO, CI, SVR.Timepoint: Pre operative, intra operative and post operative | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Need for additional mechanical or pharmacological support. b) Duration to Wean off from mechanical ventilator support. c) Dosage and duration of inotropic supports. d) Requirement of additional drugs (dosage and duration) to combat the adverse effects e) Duration of ICU stay. f) Vasoactive-inotropic score for predicting surgical outcome.Timepoint: one week | — |
Countries
India
Contacts
Public ContactMeenu Anna John
CMC Vellore
Outcome results
None listed