Health Condition 1: I712- Thoracic aortic aneurysm, withoutrupture
Conditions
Interventions
None listed
Sponsors
RGUHS Teaching Faculty Advance Research Grant Edit Delete
Eligibility
Inclusion criteria
Inclusion criteria: a.Patients having inflammatory and non-inflammatory aortic diseases b.Patients undergoing Aortic valve repair surgeries c.Patients undergoing Aortic replacement surgeries d.Patients older than 18 years e.Patients of either gender f.Patients from only Indian will be included in the study.
Exclusion criteria
Exclusion criteria: a.Patientâ??s infective disease process such as infective endocarditis or mycotic aneurysms. b.Patients with iatrogenic aneurysm or dissection. c.Patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identify the role of Gut-Heart Axis in the progression of Thoracic Aortic AneurysmTimepoint: 6 weeks, 6 Months, 1 year, 3 years and 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Understand and identify the microbial composition in aorta and GI tract of patients with TAA 2. Understand the correlation between change in the gut microbiota and disease progression in TAA 3.Gain a deeper understanding of the metabolic and inflammatory pathways being affected by the microbial dysbiosis both at the gut and the heart regions in a clinically diagnosed TAA patient 4.Understand the gut microbial dysbiosis and its role in the aortic remodeling/disease progression Timepoint: Pre surgery, post surgery 6months, 1year, 3 years and 5 years | — |
Countries
India
Contacts
Public ContactDr Varun Shetty
Narayana Hrudayalaya
Outcome results
None listed